UConn AgingNet Faculty

Joseph A. Lorenzo, M.D.

Academic Title: Professor of Medicine, Director of Bone Biology Research 

Department/Center: Medicine/Endocrinology 

Education: MD, State University of New York, Downstate Medical Center 

Residency: University of Illinois, Internal Medicine 

Research Interests: Regulation of osteoclastogenesis by gonadal hormones and cytokines 

Selected Publications: 

Lee SK, and Lorenzo JA Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin mRNA expression in murine bone marrow cultures: Correlation with osteoclast-like cell formation.  Endocrinology 140:3552-3561, 1999.

Okada Y, Lorenzo JA, Freeman AM, Tomita M, Morham SG, Raisz LG and Pilbeam CC.  Prostaglandin G/H synthetase-2 is required for maximal stimulation of osteoclast-like cell formation in murine marrow and spleen cultures. Journal of Clinical Investigation 105:823-832, 2000. 

Grčević D, Lee SK, Marusic A and Lorenzo JA.  Depletion of CD4 and CD8 T lymphocytes in mice in vivo enhances 1,25 (OH)2 vitamin D3-stimulated osteoclast-like cell formation in vitro by a mechanism that is dependent on prostaglandin synthesis.  Journal of Immunology 165: 4231- 4238, 2000.

Lee SK, Kalinowski J, Jastrzebski S and Lorenzo JA  1,25 (OH)2 Vitamin D3-stimulated osteoclast formation in spleen-osteoblast cocultures is mediated, in part, by enhanced IL-1a and RANK-ligand production in osteoblasts.  Journal of Immunology 169: 2374-80, 2002. 

Lorenzo J.A new hypothesis for how sex steroid hormones regulate bone mass. J Clin Invest. 2003 Jun;111(11):1641-3.

Contact Information: 
Phone:   860-679-8199
Fax:       860-679-1040
E-mail:  JLorenzo@nso2.uchc.edu